Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets.
Kurachi T, Shinozuka K, Yoshihara C, Yano-Nashimoto S, Murayama AY, Hata J, Haga Y, Okano H, Kuroda KO.
Commun Biol. 2023 Dec 5;6(1):1231. doi: 10.1038/s42003-023-05593-5.
PMID: 38052969
Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs.
Supakul S, Hatakeyama Y, Leventoux N, Itsuno M, Numata N, Hiramine H, Morimoto S, Iwata A, Maeda S, Okano H.
Aging Brain. 2023 Nov 19;4:100101. doi: 10.1016/j.nbas.2023.100101. eCollection 2023.
PMID: 38045491
Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy.
Sakakura S, Inagaki E, Sayano T, Yamazaki R, Fusaki N, Hatou S, Hirayama M, Tsubota K, Negishi K, Okano H, Shimmura S.
Regen Ther. 2023 Nov 10;24:592-601. doi: 10.1016/j.reth.2023.11.001. eCollection 2023 Dec.
PMID: 38034859
Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis.
Okano H, Morimoto S, Kato C, Nakahara J, Takahashi S.
J Neurochem. 2023 Dec;167(5):603-614. doi: 10.1111/jnc.16005. Epub 2023 Nov 12.
PMID: 37952981
A shift of brain network hub after spinal cord injury.
Matsubayashi K, Shinozaki M, Hata J, Komaki Y, Nagoshi N, Tsuji O, Fujiyoshi K, Nakamura M, Okano H.
Front Mol Neurosci. 2023 Oct 17;16:1245902. doi: 10.3389/fnmol.2023.1245902. eCollection 2023.
PMID: 37915973
Proteomic characterization of aging-driven changes in the mouse brain by co-expression network analysis.
Tsumagari K, Sato Y, Aoyagi H, Okano H, Kuromitsu J.
Sci Rep. 2023 Oct 24;13(1):18191. doi: 10.1038/s41598-023-45570-w.
PMID: 37875604
Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation.
Suematsu Y, Nagoshi N, Shinozaki M, Kase Y, Saijo Y, Hashimoto S, Shibata T, Kajikawa K, Kamata Y, Ozaki M, Yasutake K, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H.
Inflamm Regen. 2023 Oct 16;43(1):50. doi: 10.1186/s41232-023-00298-y.
PMID: 37845736 プレスリリース
Regenerative medicine strategies for chronic complete spinal cord injury.
Hashimoto S, Nagoshi N, Nakamura M, Okano H.
Neural Regen Res. 2024 Apr;19(4):818-824. doi: 10.4103/1673-5374.382230.
PMID: 37843217
Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis.
Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, Takubo K, Kubota Y.
Nat Cell Biol. 2023 Oct;25(10):1415-1425. doi: 10.1038/s41556-023-01240-7. Epub 2023 Oct 5.
PMID: 37798545
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Abe Y, Yagishita S, Sano H, Sugiura Y, Dantsuji M, Suzuki T, Mochizuki A, Yoshimaru D, Hata J, Matsumoto M, Taira S, Takeuchi H, Okano H, Ohno N, Suematsu M, Inoue T, Nambu A, Watanabe M, Tanaka KF.
Cell Rep Med. 2023 Oct 17;4(10):101208. doi: 10.1016/j.xcrm.2023.101208. Epub 2023 Sep 28.
PMID: 37774703
Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study.
Sasaki T, Nishimoto Y, Hirata T, Abe Y, Hirose N, Takayama M, Takebayashi T, Okano H, Arai Y.
Elife. 2023 Sep 28;12:e86309. doi: 10.7554/eLife.86309.
PMID: 37768324
The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration.
Ono-Minagi H, Nohno T, Serizawa T, Usami Y, Sakai T, Okano H, Ohuchi H.
Int J Mol Sci. 2023 Sep 5;24(18):13692. doi: 10.3390/ijms241813692.
PMID: 37761995
Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines.
Yokota M, Yoshino Y, Hosoi M, Hashimoto R, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
Front Cell Dev Biol. 2023 Sep 8;11:1171440. doi: 10.3389/fcell.2023.1171440. eCollection 2023.
PMID: 37745304
Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice.
Katada Y, Yoshida K, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Kandori H, Tsubota K, Kurihara T.
iScience. 2023 Aug 25;26(10):107716. doi: 10.1016/j.isci.2023.107716. eCollection 2023 Oct 20.
PMID: 37720108
Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing.
Yoshimatsu S, Okahara J, Yoshie J, Igarashi Y, Nakajima R, Sanosaka T, Qian E, Sato T, Kobayashi H, Morimoto S, Kishi N, Pillis DM, Malik P, Noce T, Okano H.
Cell Rep Methods. 2023 Sep 25;3(9):100590. doi: 10.1016/j.crmeth.2023.100590. Epub 2023 Sep 14.
PMID: 37714158
Gene therapy using genome-edited iPS cells for targeting malignant glioma.
Tamura R, Miyoshi H, Imaizumi K, Yo M, Kase Y, Sato T, Sato M, Morimoto Y, Sampetrean O, Kohyama J, Shinozaki M, Miyawaki A, Yoshida K, Saya H, Okano H, Toda M.
Bioeng Transl Med. 2022 Sep 10;8(5):e10406. doi: 10.1002/btm2.10406. eCollection 2023 Sep.
PMID: 37693056
Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal.
Hosoya M, Kitama T, Shimanuki MN, Nishiyama T, Oishi N, Okano H, Ozawa H.
Front Immunol. 2023 Aug 22;14:1229414. doi: 10.3389/fimmu.2023.1229414. eCollection 2023.
PMID: 37675123
Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.
Watanabe H, Murakami R, Tsumagari K, Morimoto S, Hashimoto T, Imaizumi K, Sonn I, Yamada K, Saito Y, Murayama S, Iwatsubo T, Okano H.
Stem Cell Reports. 2023 Aug 14:S2213-6711(23)00301-6. doi: 10.1016/j.stemcr.2023.08.002. Online ahead of print.
PMID: 37657448 プレスリリース
Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula.
Kobayashi H, Ueda K, Morimoto S, Ishikawa M, Leventoux N, Sasaki R, Hirokawa Y, Kokubo Y, Okano H.
Neurol Sci. 2023 Aug 24. doi: 10.1007/s10072-023-07000-7. Online ahead of print.
PMID: 37615876
A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Nakamura M, Okano H, Nagoshi N.
Medicina (Kaunas). 2023 Jul 1;59(7):1235. doi: 10.3390/medicina59071235.
PMID: 37512047
Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal.
Hosoya M, Iwabu K, Kitama T, Nishiyama T, Oishi N, Okano H, Ozawa H.
Sci Rep. 2023 Jul 21;13(1):11789. doi: 10.1038/s41598-023-39003-x.
PMID: 37479821
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M.
Nat Aging. 2023 Aug;3(8):1001-1019. doi: 10.1038/s43587-023-00464-4. Epub 2023 Jul 20.
PMID: 37474791
Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.
Kawamura Y, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T, Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K.
EMBO J. 2023 Aug 15;42(16):e111133. doi: 10.15252/embj.2022111133. Epub 2023 Jul 11.
PMID: 37431790
The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain.
Skibbe H, Rachmadi MF, Nakae K, Gutierrez CE, Hata J, Tsukada H, Poon C, Schlachter M, Doya K, Majka P, Rosa MGP, Okano H, Yamamori T, Ishii S, Reisert M, Watakabe A.
PLoS Biol. 2023 Jun 29;21(6):e3002158. doi: 10.1371/journal.pbio.3002158. eCollection 2023 Jun.
PMID: 37384809
Mapping of Notch signaling in the developing organ of Corti in common marmosets.
Hosoya M, Fujioka M, Okano H, Ozawa H.
Front Neuroanat. 2023 Jun 7;17:1188886. doi: 10.3389/fnana.2023.1188886. eCollection 2023.
PMID: 37351521
Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.
Katada Y, Kunimi H, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tanaka KF, Tsubota K, Kurihara T.
Mol Ther Methods Clin Dev. 2023 May 12;30:1-13. doi: 10.1016/j.omtm.2023.05.011. eCollection 2023 Sep 14.
PMID: 37324975
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms.
Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H.
Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721. Epub 2023 Jun 14.
PMID: 37315111
Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation.
Isoda M, Sanosaka T, Tomooka R, Mabuchi Y, Shinozaki M, Andoh-Noda T, Banno S, Mizota N, Yamaguchi R, Okano H, Kohyama J.
Commun Biol. 2023 Jun 7;6(1):611. doi: 10.1038/s42003-023-04995-9.
PMID: 37286713
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H.
Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017.
PMID: 37267913 プレスリリース
Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling.
Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Shimul RI, Niwa JI, Katsuno M, Sobue G, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y.
Sci Rep. 2023 May 25;13(1):8146. doi: 10.1038/s41598-023-34445-9.
PMID: 37231024
Local and long-distance organization of prefrontal cortex circuits in the marmoset brain.
Watakabe A, Skibbe H, Nakae K, Abe H, Ichinohe N, Rachmadi MF, Wang J, Takaji M, Mizukami H, Woodward A, Gong R, Hata J, Van Essen DC, Okano H, Ishii S, Yamamori T.
Neuron. 2023 May 9:S0896-6273(23)00338-0. doi: 10.1016/j.neuron.2023.04.028. Online ahead of print.
PMID: 37196659
Dissecting calvarial bones and sutures at single-cell resolution.
Li B, Li J, Fan Y, Zhao Z, Li L, Okano H, Ouchi T.
Biol Rev Camb Philos Soc. 2023 May 12. doi: 10.1111/brv.12975. Online ahead of print.
PMID: 37171117
Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.
Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group.
J Neurol Neurosurg Psychiatry. 2023 May 4:jnnp-2022-330851. doi: 10.1136/jnnp-2022-330851. Online ahead of print.
PMID: 37142397
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes.
Kondo T, Ebinuma I, Tanaka H, Nishikawa Y, Komiya T, Ishikawa M, Okano H.
Int J Mol Sci. 2023 Apr 10;24(8):6987. doi: 10.3390/ijms24086987.
PMID: 37108151
Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range.
Hata J, Nakae K, Tsukada H, Woodward A, Haga Y, Iida M, Uematsu A, Seki F, Ichinohe N, Gong R, Kaneko T, Yoshimaru D, Watakabe A, Abe H, Tani T, Hamda HT, Gutierrez CE, Skibbe H, Maeda M, Papazian F, Hagiya K, Kishi N, Ishii S, Doya K, Shimogori T, Yamamori T, Tanaka K, Okano HJ, Okano H.
Sci Data. 2023 Apr 27;10(1):221. doi: 10.1038/s41597-023-02121-2.
PMID: 37105968 プレスリリース
The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: the second phase of the archive of digital records.
Sakai T, Hata J, Shintaku Y, Ohta H, Sogabe K, Mori S, Miyabe-Nishiwaki T, Okano HJ, Hamada Y, Hirabayashi T, Minamimoto T, Sadato N, Okano H, Oishi K.
Neuroimage. 2023 Apr 7:120096. doi: 10.1016/j.neuroimage.2023.120096. Online ahead of print.
PMID: 37031828 プレスリリース
Neuroprotective effects of genome-edited human iPS cell-derived neural stem/progenitor cells on traumatic brain injury.
Imai R, Tamura R, Yo M, Sato M, Fukumura M, Takahara K, Kase Y, Okano H, Toda M.
Stem Cells. 2023 Apr 8:sxad028. doi: 10.1093/stmcls/sxad028. Online ahead of print.
PMID: 37029780 プレスリリース
A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1.
Qian E, Uemura M, Kobayashi H, Nakamura S, Ozawa F, Yoshimatsu S, Ishikawa M, Onodera O, Morimoto S, Okano H.
Inflamm Regen. 2023 Apr 3;43(1):23. doi: 10.1186/s41232-023-00273-7.
PMID: 37009886
Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids.
Kodera T, Takeuchi RF, Takahashi S, Suzuki K, Kassai H, Aiba A, Shiozawa S, Okano H, Osakada F.
Biochem Biophys Res Commun. 2023 May 21;657:119-127. doi: 10.1016/j.bbrc.2023.03.019. Epub 2023 Mar 11.
PMID: 37002985
Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review.
Inoue M, Yamaguchi R, He CCJ, Ikeda A, Okano H, Kohyama J.
Stem Cell Investig. 2023 Mar 10;10:6. doi: 10.21037/sci-2022-037. eCollection 2023.
PMID: 36970397
The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D cultures.
Kase Y, Sonn I, Goto M, Murakami R, Sato T, Okano H.
Exp Neurol. 2023 Mar 11;363:114379. doi: 10.1016/j.expneurol.2023.114379. Online ahead of print.
PMID: 36914084
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.
Tamura R, Iwanami A, Ohara K, Nishimoto M, Pareira ES, Miwa T, Tsuzaki N, Kuranari Y, Morimoto Y, Toda M, Okano H, Nakamura M, Yoshida K, Sasaki H.
Brain Tumor Pathol. 2023 Mar 9. doi: 10.1007/s10014-023-00453-w. Online ahead of print.
PMID: 36892668
Influence of Diffusion Time and Temperature on Restricted Diffusion Signal: A Phantom Study.
Oshiro H, Hata J, Nakashima D, Hayashi N, Haga Y, Hagiya K, Yoshimaru D, Okano H.
Magn Reson Med Sci. 2023 Feb 8. doi: 10.2463/mrms.mp.2022-0103. Online ahead of print.
PMID: 36754420
Epigenetic profile of Japanese supercentenarians: a cross-sectional study.
Komaki S, Nagata M, Arai E, Otomo R, Ono K, Abe Y, Ohmomo H, Umekage S, Shinozaki NO, Hachiya T, Sutoh Y, Otsuka-Yamasaki Y, Arai Y, Hirose N, Yoneyama A, Okano H, Sasaki M, Kanai Y, Shimizu A.
Lancet Healthy Longev. 2023 Feb;4(2):e83-e90. doi: 10.1016/S2666-7568(23)00002-8.
PMID: 36738748
Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury.
Hashimoto S, Nagoshi N, Shinozaki M, Nakanishi K, Suematsu Y, Shibata T, Kawai M, Kitagawa T, Ago K, Kamata Y, Yasutake K, Koya I, Ando Y, Minoda A, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H.
Biomaterials. 2023 Apr;295:122002. doi: 10.1016/j.biomaterials.2023.122002. Epub 2023 Jan 26.
PMID: 36736008 プレスリリース
Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Shibata S, Shinozaki M, Shindo T, Hashimoto S, Kawai M, Kitagawa T, Ago K, Matsumoto M, Nakamura M, Okano H, Nagoshi N.
Stem Cells Transl Med. 2023 Mar 3;12(2):83-96. doi: 10.1093/stcltm/szac089.
PMID: 36647673 プレスリリース
Generation of two induced pluripotent stem cell lines from individuals without auditory disorders.
Okura S, Ishii H, Suzuki A, Saegusa C, Fujiki K, Sugano K, Suzuki N, Saeki T, Matsuzaki S, Ozawa H, Fujioka M, Hosoya M, Okano H.
Stem Cell Res. 2023 Mar;67:103017. doi: 10.1016/j.scr.2023.103017. Epub 2023 Jan 4.
PMID: 36630839
