Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential.
Fujii-Tezuka R, Ishige-Wada M, Nagoshi N, Okano H, Mugishima H, Takahashi S, Morioka I, Matsumoto T.
Regen Ther. 2020 Dec 24;16:1-11. doi: 10.1016/j.reth.2020.12.002. eCollection 2021 Mar.
PMID: 33426237 [PubMed]
Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood.
Al-Bakri Z, Ishige-Wada M, Fukuda N, Yoshida-Noro C, Nagoshi N, Okano H, Mugishima H, Matsumoto T.
Regen Ther. 2020 Jul 18;15:53-63. doi: 10.1016/j.reth.2020.06.001. eCollection 2020 Dec.
PMID: 33426202 [PubMed]
Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression.
Nemoto A, Kobayashi R, Yoshimatsu S, Sato Y, Kondo T, Yoo AS, Shiozawa S, Okano H.
Cells. 2020 Dec 22;10(1):E6. doi: 10.3390/cells10010006.
PMID: 33375083 [PubMed]
Optimization and validation of diffusion MRI-based fiber tracking with neural tracer data as a reference.
Gutierrez CE, Skibbe H, Nakae K, Tsukada H, Lienard J, Watakabe A, Hata J, Reisert M, Woodward A, Yamaguchi Y, Yamamori T, Okano H, Ishii S, Doya K.
Sci Rep. 2020 Dec 18;10(1):21285. doi: 10.1038/s41598-020-78284-4.
PMID: 33339834 [PubMed]
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells.
Harada S, Mabuchi Y, Kohyama J, Shimojo D, Suzuki S, Kawamura Y, Araki D, Suyama T, Kajikawa M, Akazawa C, Okano H, Matsuzaki Y.
Stem Cells. 2020 Dec 18. doi: 10.1002/stem.3317. Online ahead of print.
PMID: 33338299 [PubMed]
Human Astrocytes Model Derived from Induced Pluripotent Stem Cells.
Leventoux N, Morimoto S, Imaizumi K, Sato Y, Takahashi S, Mashima K, Ishikawa M, Sonn I, Kondo T, Watanabe H, Okano H.
Cells. 2020 Dec 13;9(12):E2680. doi: 10.3390/cells9122680.
PMID: 33322219 [PubMed]
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication.
Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y.
FEBS Open Bio. 2020 Dec 10. doi: 10.1002/2211-5463.13060. Online ahead of print.
PMID: 33301617
Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models.
Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman NA, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y.
Commun Biol. 2020 Dec 9;3(1):767. doi: 10.1038/s42003-020-01483-2.
PMID: 33299105[PubMed]
The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets.
Murayama AY, Kuwako KI, Okahara J, Bae BI, Okuno M, Mashiko H, Shimogori T, Walsh CA, Sasaki E, Okano H.
Sci Rep. 2020 Dec 9;10(1):21516. doi: 10.1038/s41598-020-78608-4.
PMID: 33299078 [PubMed]
Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development.
Suzuki T, Adachi S, Kikuguchi C, Shibata S, Nishijima S, Kawamoto Y, Iizuka Y, Koseki H, Okano H, Natsume T, Yamamoto T.
Int J Mol Sci. 2020 Dec 7;21(23):9319. doi: 10.3390/ijms21239319.
PMID: 33297405 [PubMed]
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain.
Kawamura A, Abe Y, Seki F, Katayama Y, Nishiyama M, Takata N, Tanaka KF, Okano H, Nakayama KI. Mol Brain. 2020 Nov 23;13(1):160. doi: 10.1186/s13041-020-00699-x.[PubMed]
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury.
Kamata Y, Isoda M, Sanosaka T, Shibata R, Ito S, Okubo T, Shinozaki M, Inoue M, Koya I, Shibata S, Shindo T, Matsumoto M, Nakamura M, Okano H, Nagoshi N, Kohyama J.
Stem Cells Transl Med. 2020 Nov 23. doi: 10.1002/sctm.20-0269. [PubMed][プレスリリース]
Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK2. Ohta E, Sone T, Ukai H, Hisamatsu T, Kitagawa T, Ishikawa M, Nagai M, Ueda HR, Obata F, Okano H.
Stem Cell Res. 2020 Nov 3;49:102073. doi: 10.1016/j.scr.2020.102073.[PubMed]
Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.
Oiwa Y, Oka K, Yasui H, Higashikawa K, Bono H, Kawamura Y, Miyawaki S, Watarai A, Kikusui T, Shimizu A, Okano H, Kuge Y, Kimura K, Okamatsu-Ogura Y, Miura K.
Sci Rep. 2020 Nov 10;10(1):19488. doi: 10.1038/s41598-020-74929-6. PMID: 33173084 [PubMed]
Modeling neurodevelopment in a dish with pluripotent stem cells.
Imaizumi K, Okano H. Dev Growth Differ. 2020 Nov 3. doi: 10.1111/dgd.12699. Online ahead of print. PMID: 33141454[PubMed]
Regenerative therapy for spinal cord injury using iPSC technology.
Nagoshi N, Okano H, Nakamura M. Inflamm Regen. 2020 Oct 16;40:40. doi: 10.1186/s41232-020-00149-0. eCollection 2020. PMID: 33088363 [PubMed]
New trends in cellular therapy. Okano H, Sipp D.
Development. 2020 Sep 17;147(18):dev192567. doi: 10.1242/dev.192567.
PMID: 32943426[PubMed]
Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders.
Kase Y, Okano H. Inflamm Regen. 2020 Sep 11;40:32. doi: 10.1186/s41232-020-00143-6. eCollection 2020. PMID: 32934757[PubMed]
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells. Kajikawa K, Imaizumi K, Shinozaki M, Shibata S, Shindo T, Kitagawa T, Shibata R, Kamata Y, Kojima K, Nagoshi N, Matsumoto M, Nakamura M, Okano H.
Mol Brain. 2020 Sep 3;13(1):120. doi: 10.1186/s13041-020-00662-w. PMID: 32883317 [PubMed]
Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms. Yumoto T, Kimura M, Nagatomo R, Sato T, Utsunomiya S, Aoki N, Kitaura M, Takahashi K, Takemoto H, Watanabe H, Okano H, Yoshida F, Nao Y, Tomita T. Mol Autism. 2020 Sep 1;11(1):68. doi: 10.1186/s13229-020-00373-y.
PMID: 32873342 [PubMed]
Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research. Feng G, Jensen FE, Greely HT, Okano H, Treue S, Roberts AC, Fox JG, Caddick S, Poo MM, Newsome WT, Morrison JH. Proc Natl Acad Sci U S A. 2020[PubMed]
Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Hirata T, Arai Y, Yuasa S, Abe Y, Takayama M, Sasaki T, Kunitomi A, Inagaki H, Endo M, Morinaga J, Yoshimura K, Adachi T, Oike Y, Takebayashi T, Okano H, Hirose N. Nat Commun. 2020 Jul 30;11(1):3820. doi: 10.1038/s41467-020-17636-0.
PMID: 32732919 [PubMed][プレスリリース]
Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.
Saito K, Michon F, Yamada A, Inuzuka H, Yamaguchi S, Fukumoto E, Yoshizaki K, Nakamura T, Arakaki M, Chiba Y, Ishikawa M, Okano H, Thesleff I, Fukumoto S.
iScience. 2020 Jun 30;23(7):101329. doi: 10.1016/j.isci.2020.101329. Online ahead of print. PMID: 32674056 [PubMed]
Generation of an ALS human iPSC line KEIOi001-A from peripheral blood of a Charcot disease-affected patient carrying TARDBP p.N345K heterozygous SNP mutation.
Leventoux N, Morimoto S, Hara K, Nakamura S, Ozawa F, Mitsuzawa S, Akiyama T, Nishiyama A, Suzuki N, Warita H, Aoki M, Okano H. Stem Cell Res. 2020 [PubMed]
Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.
Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, Kamijuku H, Ogawa M, Suzuki T, Mukai S, Shimmura S, Okano H, Takeuchi T, Kawakami Y, Ogawa Y, Tsubota K.
FASEB J. 2020 Jul 3. doi: 10.1096/fj.201900218R. Online ahead of print. PMID: 32619061 [PubMed]
Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells.
Saegusa C, Hosoya M, Nishiyama T, Saeki T, Fujimoto C, Okano H, Fujioka M, Ogawa K.
Laryngoscope Investig Otolaryngol. 2020 May 29;5(3):520-528. doi: 10.1002/lio2.392. eCollection 2020 Jun. PMID: 32596496 [PubMed]
Steps towards COVID-19 suppression.
Okano H, Seino KI.
Version 2. Inflamm Regen. 2020 Jun 22;40:13. doi: 10.1186/s41232-020-00120-z. eCollection 2020. PMID: 32582400 [PubMed]
Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?
Kase Y, Shimazaki T, Okano H. Inflamm Regen. 2020 Jun 18;40:10. doi: 10.1186/s41232-020-00122-x. eCollection 2020. PMID: 32566044 [PubMed]
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset. Heide M, Haffner C, Murayama A, Kurotaki Y, Shinohara H, Okano H, Sasaki E, Huttner WB. Science. 2020 Jun 18:eabb2401. doi: 10.1126/science.abb2401. Online ahead of print. PMID: 32554627[PubMed][プレスリリース]
The liver-brain-gut neural arc maintains the Treg cell niche in the gut.
Teratani T, Mikami Y, Nakamoto N, Suzuki T, Harada Y, Okabayashi K, Hagihara Y, Taniki N, Kohno K, Sibata S, Miyamoto K, Ishigame H, Chu PS, Sujino T, Suda W, Hattori M, Matsui M, Okada T, Okano H, Inoue M, Yada T, Kitagawa Y, Yoshimura A, Tanida M, Tsuda M, Iwasaki Y, Kanai T.
Nature. 2020 Jun 11. doi: 10.1038/s41586-020-2425-3. Online ahead of print.
PMID: 32526765 [PubMed]
Quantitative analysis of intervertebral disc degeneration using Q-space imaging in a rat model.
Nakashima D, Fujita N, Hata J, Komaki Y, Suzuki S, Nagura T, Fujiyoshi K, Watanabe K, Tsuji T, Okano H, Jinzaki M, Matsumoto M, Nakamura M.
J Orthop Res. 2020 May 27. doi: 10.1002/jor.24757. Online ahead of print.
PMID: 32458477 [PubMed]
Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC.
Morimoto S, Ishikawa M, Watanabe H, Isoda M, Takao M, Nakamura S, Ozawa F, Hirokawa Y, Kuzuhara S, Okano H, Kokubo Y.
Antioxidants (Basel). 2020 May 14;9(5):423. doi: 10.3390/antiox9050423.
PMID: 32422904 [PubMed]
Controlling gene activation by enhancers through a drug-inducible topological insulator.
Tsujimura T, Takase O, Yoshikawa M, Sano E, Hayashi M, Hoshi K, Takato T, Toyoda A, Okano H, Hishikawa K.
Elife. 2020 May 5;9:e47980. doi: 10.7554/eLife.47980.
PMID: 32369019 [PubMed]
A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling.
Shiba-Fukushima K, Inoshita T, Sano O, Iwata H, Ishikawa KI, Okano H, Akamatsu W, Imai Y, Hattori N. iScience. 2020 May 22;23(5):101048. doi: 10.1016/j.isci.2020.101048. Epub 2020 Apr 11.PMID: 32335362 [PubMed]
Phase I/II Study of Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor in Patients with Acute Spinal Cord Injury: A Double-Blind, Randomized Clinical Trial of Safety and Efficacy.
Nagoshi N, Tsuji O, Kitamura K, Suda K, Maeda T, Yato Y, Abe T, Hayata D, Matsumoto M, Okano H, Nakamura M. J Neurotrauma. 2020 May 22. doi: 10.1089/neu.2019.6854. Online ahead of print.
PMID: 32323609 [PubMed]
The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.
Hosoya M, Fujioka M, Murayama AY, Okano H, Ogawa K. FEBS J. 2020 Apr 23. doi: 10.1111/febs.15341. Online ahead of print.
PMID: 32323465[PubMed]
Analysis of the nucleocytoplasmic shuttling RNA-binding protein HNRNPU using optimized HITS-CLIP method. Yugami M, Okano H, Nakanishi A, Yano M. PLoS One. 2020 Apr 17;15(4):e0231450. doi: 10.1371/journal.pone.0231450. eCollection 2020. PMID: 32302342 [PubMed]
“Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development.” Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. Nat Commun. 2020 Apr 3;11(1):1674. doi: 10.1038/s41467-020-15412-8. PMID: 32245946 [PubMed]
“An improved de novo genome assembly of the common marmoset genome yields improved contiguity and increased mapping rates of sequence data.”
Jayakumar V, Ishii H, Seki M, Kumita W, Inoue T, Hase S, Sato K, Okano H, Sasaki E, Sakakibara Y. BMC Genomics. 2020 Apr 2;21(Suppl 3):243. doi: 10.1186/s12864-020-6657-2. PMID: 32241258 [PubMed]
“Primed to naïve-like conversion of the common marmoset embryonic stem cells.”
Shiozawa S, Nakajima M, Okahara J, Kuortaki Y, Kisa F, Yoshimatsu S, Nakamura M, Koya I, Yoshimura M, Sasagawa Y, Nikaido I, Sasaki E, Okano H. Stem Cells Dev. 2020 Mar 18. doi: 10.1089/scd.2019.0259. PMID: 32188344 [PubMed]
“Generation of a male common marmoset embryonic stem cell line DSY127-BV8VT1 carrying double reporters specific for the germ cell linage using the CRISPR-Cas9 and PiggyBac transposase systems.” Yoshimatsu S, Sato T, Yamamoto M, Sasaki E, Nakajima M, Nakamura M, Shiozawa S, Noce T, Okano H. Stem Cell Res. 2020 Feb 21;44:101740. doi: 10.1016/j.scr.2020.101740. PMID: 32151954 [PubMed]
“miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro” M Ishikawa, T Aoyama, S Shibata , T Sone, H Miyoshi, H Watanabe, M Nakamura, S Morota, H Uchino, A Yoo, H Okano. Cells 2020 Feb 25;9(3). pii: E532. doi: 10.3390/cells9030532. PMID: 32106535 [PubMed]
“Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.” Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Nat Commun. 2020 Feb 26;11(1):859. doi: 10.1038/s41467-020-14697-z. [PubMed]
“Awake functional MRI detects neural circuit dysfunction in a mouse model of autism.” Tsurugizawa T, Tamada K, Ono N, Karakawa S, Kodama Y, Debacker C, Hata J, Okano H, Kitamura A, Zalesky A, Takumi T.
Sci Adv. 2020 Feb 5;6(6):eaav4520. doi: 10.1126/sciadv.aav4520. eCollection 2020 Feb. [PubMed]
“Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect.” Tamura R, Miyoshi H, Morimoto Y, Oishi Y, Sampetrean O, Iwasawa C, Mine Y, Saya H, Yoshida K, Okano H, Toda M.
Hum Gene Ther. 2020 Feb 19. doi: 10.1089/hum.2019.326. [PubMed]
“Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs.” Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, de Araújo Herculano B, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y.
Mol Brain. 2020 Feb 19;13(1):18. doi: 10.1186/s13041-020-0561-1. [PubMed] プレスリリース
“Reprogramming of chimpanzee fibroblasts into a multipotent cancerous but not fully pluripotent state by transducing iPSC factors in 2i/LIF culture.”
Lin ZY, Nakai R, Hirai H, Kozuka D, Katayama S, Nakamura SI, Okada S, Kitajima R, Imai H, Okano H, Imamura M
Differentiation 2020 Feb 4;112:67-76. doi: 10.1016/j.diff.2020.01.002. [PubMed]
“YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology.”
Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H.
Nat Commun. 2020 Jan 24;11(1):507. doi: 10.1038/s41467-020-14353-6. [PubMed]
“In vivo monitoring of remnant undifferentiated neural cells following human iPS cell-derived neural stem/progenitor cells transplantation.”
Tanimoto Y, Yamasaki T, Nagoshi N, Nishiyama Y, Nori S, Nishimura S, Iida T, Ozaki M, Tsuji O, Ji B, Aoki I, Jinzaki M, Matsumoto M, Fujibayashi Y, Zhang MR, Nakamura M, Okano H. Stem Cells Transl Med. 2020 Jan 6. doi: 10.1002/sctm.19-0150. [PubMed] プレスリリース
“Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.”
Okano H, Yasuda D, Fujimori K, Morimoto S, Takahashi S.
Trends Pharmacol Sci. 2020 Jan 8. pii: S0165-6147(19)30274-3. doi: 10.1016/j.tips.2019.12.002. [PubMed]
