2019年

Okano H. Dr. Seiji Ogawa and the Past, Present, and Future of Functional MRI Research. Keio J Med. 2019;68(4):71-72. doi: 10.2302/kjm.68-4_Editorial.[PubMed]

Sonn I, Nakamura M, Renault-Mihara F, Okano H. Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage-Mediated Activation of Wnt/β-Catenin Pathway. Mol Neurobiol. 2019 Dec 17. doi: 10.1007/s12035-019-01851-y. [PubMed]

Saeki T, Hosoya M, Shibata S, Okano H, Fujioka M, Ogawa K. Distribution of tight junctions in the primate cochlear lateral wall.   Neurosci Lett. 2019 Dec 12:134686. doi: 10.1016/j.neulet.2019.134686. [PubMed]

Tamura R, Miyoshi H, Yoshida K, Okano H, Toda M. Recent progress in the research of suicide gene therapy for malignant glioma. Neurosurg Rev. 2019 Nov 28. doi: 10.1007/s10143-019-01203-3. [PubMed]

Hashimoto K, Kouno T, Ikawa T, Hayatsu N, Miyajima Y, Yabukami H, Terooatea T, Sasaki T, Suzuki T, Valentine M, Pascarella G, Okazaki Y, Suzuki H, Shin JW, Minoda A, Taniuchi I, Okano H, Arai Y, Hirose N, Carninci P. Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. Proc Natl Acad Sci U S A. 2019 Nov 12. pii: 201907883. doi: 10.1073/pnas.1907883116. [PubMed]

Kinoshita M, Fujimoto C, Iwasaki S, Kashio A, Kikkawa YS, Kondo K, Okano H, Yamasoba T. Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris. Front Cell Neurosci. 2019 Oct 25;13:481. doi: 10.3389/fncel.2019.00481. eCollection 2019. [PubMed]

Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 2019 Nov 2. doi: 10.1507/endocrj.EJ19-0313. [PubMed]

Ide M, Ohnishi T, Toyoshima M, Balan S, Maekawa M, Shimamoto-Mitsuyama C, Iwayama Y, Ohba H, Watanabe A, Ishii T, Shibuya N, Kimura Y, Hisano Y, Murata Y, Hara T, Morikawa M, Hashimoto K, Nozaki Y, Toyota T, Wada Y, Tanaka Y, Kato T, Nishi A, Fujisawa S, Okano H, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T. Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. EMBO Mol Med. 2019 Oct 28:e10695. doi: 10.15252/emmm.201910695. [PubMed]

Lam M, Sanosaka T, Lundin A, Imaizumi K, Etal D, Karlsson FH, Clausen M, Cairns J, Hicks R, Kohyama J, Kele M, Okano H, Falk A. Single cell study of neural stem cells derived from human iPSCs reveal distinct progenitor populations with neurogenic and gliogenic potential. Genes Cells. 2019 Oct 25. doi: 10.1111/gtc.12731. [PubMed]

Ando K, Inoue T, Hikishima K, Komaki Y, Kawai K, Inoue R, Nishime C, Nishinaka E, Urano K, Okano H. Measurement of baseline locomotion and other behavioral traits in a common marmoset model of Parkinson’s disease established by a single administration regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: providing reference data for efficacious preclinical evaluations. Behav Pharmacol. 2019 Oct 15. doi: 10.1097/FBP.0000000000000509. [PubMed]

Arai Y, Cwetsch AW, Coppola E, Cipriani S, Nishihara H, Kanki H, Saillour Y, Freret-Hodara B, Dutriaux A, Okada N, Okano H, Dehay C, Nardelli J, Gressens P, Shimogori T, D’Onofrio G, Pierani A. Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex. Cell Rep. 2019 Oct 15;29(3):645-658.e5. doi: 10.1016/j.celrep.2019.09.007. [PubMed]

Grandjean J, Canella C, Anckaerts C, Ayrancı G, Bougacha S, Bienert T, Buehlmann D, Coletta L, Gallino D, Gass N, Garin CM, Nadkarni NA, Hübner N, Karatas M, Komaki Y, Kreitz S, Mandino F, Mechling AE, Sato C, Sauer K, Shah D, Strobelt S, Takata N, Wank I, Wu T, Yahata N, Yeow LY, Yee Y, Aoki I, Chakravarty MM, Chang WT, Dhenain M, von Elverfeldt D, Harsan LA, Hess A, Jiang T, Keliris GA, Lerch JP, Meyer-Lindenberg A, Okano H, Rudin M, Sartorius A, Van der Linden A, Verhoye M, Weber-Fahr W, Wenderoth N, Zerbi V, Gozzi A. Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis. Neuroimage. 2019 Oct 12:116278. doi: 10.1016/j.neuroimage.2019.116278. [PubMed]

Sho M, Ichiyanagi N, Imaizumi K, Ishikawa M, Morimoto S, Watanabe H, Okano H. A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition. Neurosci Res. 2019 Oct 10. pii: S0168-0102(19)30493-6. doi: 10.1016/j.neures.2019.10.006. [PubMed]

Sasaki T, Nishimoto Y, Abe Y, Takayama M, Hirose N, Okano H, Arai Y. Sex-specific effects of apolipoprotein ε4 allele on mortality in very old and centenarian Japanese men. J Gerontol A Biol Sci Med Sci. 2019 Oct 11. pii: glz242. doi: 10.1093/gerona/glz242. [PubMed]

Ikeda A, Nishioka K, Meng H, Takanashi M, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa KI, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori N. Mutations in CHCHD2 cause α-synuclein aggregation. Hum Mol Genet. 2019 Oct 10. pii: ddz241. doi: 10.1093/hmg/ddz241. [PubMed]

Serizawa T, Isotani A, Matsumura T, Nakanishi K, Nonaka S, Shibata S, Ikawa M, Okano H. Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers. Development. 2019 Oct 9. pii: dev.174938. doi: 10.1242/dev.174938. [PubMed]

Yoshimatsu S, Nakamura M, Nakajima M, Nemoto A, Sato T, Sasaki E, Shiozawa S, Okano H. Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs. Neurosci Res. 2019 Oct 3. pii: S0168-0102(19)30262-7. doi: 10.1016/j.neures.2019.09.005. [PubMed]

Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga SI, Ikeuchi T, Kaibuchi K, Okano H. Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem Cell Reports. 2019 Sep 9. pii: S2213-6711(19)30305-4. doi: 10.1016/j.stemcr.2019.08.011. [PubMed]

Ishii T, Ishikawa M, Fujimori K, Maeda T, Kushima I, Arioka Y, Mori D, Nakatake Y, Yamagata B, Nio S, Kato TA, Yang N, Wernig M, Kanba S, Mimura M, Ozaki N, Okano H. In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN. eNeuro. 2019 Sep 20. pii: ENEURO.0403-18.2019. doi: 10.1523/ENEURO.0403-18.2019. [PubMed]

Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Tsukagoshi Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M. Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy. Nat Commun. 2019 Sep 19;10(1):4262. doi: 10.1038/s41467-019-12282-7. [PubMed]

Kumita W, Sato K, Suzuki Y, Kurotaki Y, Harada T, Zhou Y, Kishi N, Sato K, Aiba A, Sakakibara Y, Feng G, Okano H, Sasaki E. Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing. Sci Rep. 2019 Sep 3;9(1):12719. doi: 10.1038/s41598-019-49110-3. [PubMed]

Yoshimatsu S, Sone T, Nakajima M, Sato T, Okochi R, Ishikawa M, Nakamura M, Sasaki E, Shiozawa S, Okano H. A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology. PLoS One. 2019 Aug 27;14(8):e0221164. doi: 10.1371/journal.pone.0221164. [PubMed]

Lohmeier J, Kaneko T, Hamm B, Makowski MR, Okano H. atlasBREX: Automated template-derived brain extraction in animal MRI. Sci Rep. 2019 Aug 21;9(1):12219. doi: 10.1038/s41598-019-48489-3. [PubMed]

Cheng YF, Chan YH, Hu CJ, Lu YC, Saeki T, Hosoya M, Saegusa C, Fujioka M, Okano H, Weng SM, Hsu CJ, Chang KH, Wu CC. Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation. Stem Cell Res. 2019 Jul 31;40:101524. doi: 10.1016/j.scr.2019.101524. [PubMed]

Abe Y, Ochiai D, Masuda H, Sato Y, Otani T, Fukutake M, Ikenoue S, Miyakoshi K, Okano H, Tanaka M. In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion. Stem Cells Transl Med. 2019 Aug 13. doi: 10.1002/sctm.19-0002. [PubMed]

Morimoto S, Takahashi S, Fukushima K, Saya H, Suzuki N, Aoki M, Okano H, Nakahara J. Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis – Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial). Regen Ther. 2019 Jul 26;11:143-166. doi: 10.1016/j.reth.2019.07.002. eCollection 2019 Dec. [PubMed]

Tabata Y, Okano H. [Modeling Familial Parkinson’s Disease Using Patient-specific Induced Pluripotent Stem Cells].  Brain Nerve. 2019 Aug;71(8):875-883. doi: 10.11477/mf.1416201368. Japanese. [PubMed]

Huo BX, Zeater N, Lin MK, Takahashi YS, Hanada M, Nagashima J, Lee BC, Hata J, Zaheer A, Grünert U, Miller MI, Rosa MGP, Okano H, Martin PR, Mitra PP. Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets. Eur J Neurosci. 2019 Jul 25. doi: 10.1111/ejn.14529. [PubMed]

Hoshino Y, Nishide K, Nagoshi N, Shibata S, Moritoki N, Kojima K, Tsuji O, Matsumoto M, Kohyama J, Nakamura M, Okano H. The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury. Sci Rep. 2019 Jul 8;9(1):9844. doi: 10.1038/s41598-019-46069-z. [PubMed]

Li Y, Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H, Ogawa K. Comparison of inner ear drug availbability of combined treatment with systemic or local drug injections alone. Neurosci Res. 2019 Jul 3. pii: S0168-0102(19)30250-0. doi: 10.1016/j.neures.2019.07.001. [PubMed]

Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, Kitajima Y, Nishiyama A, Izumi R, Morimoto S, Okada Y, Kamei T, Nishida M, Nogami M, Kaneda S, Ikeuchi Y, Mitsuhashi H, Nakayama K, Fujii T, Warita H, Okano H, Aoki M. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine. 2019 Jun 28. pii: S2352-3964(19)30388-3. doi: 10.1016/j.ebiom.2019.06.013.9 [PubMed]

Kobayashi J, Hasegawa T, Sugeno N, Yoshida S, Akiyama T, Fujimori K, Hatakeyama H, Miki Y, Tomiyama A, Kawata Y, Fukuda M, Kawahata I, Yamakuni T, Ezura M, Kikuchi A, Baba T, Takeda A, Kanzaki M, Wakabayashi K, Okano H, Aoki M. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. FASEB J. 2019 Jun 18:fj201802051R. doi: 10.1096/fj.201802051R. [PubMed]

Kanda H, Shimamura R, Koizumi-Kitajima M, Okano H. Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila. iScience. 2019 May 27;16:218-229. doi: 10.1016/j.isci.2019.05.027. [PubMed]

Nakajima M, Yoshimatsu S, Sato T, Nakamura M, Okahara J, Sasaki E, Shiozawa S, Okano H. Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming. Biochem Biophys Res Commun. 2019 Jun 6. pii: S0006-291X(19)31093-9. doi: 10.1016/j.bbrc.2019.05.175. [PubMed]

Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI. Tau isoform expression and phosphorylation in marmoset brains. J Biol Chem. 2019 Jun 5. pii: jbc.RA119.008415. doi: 10.1074/jbc.RA119.008415. [PubMed]

Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H, Narita M. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease. Brain. 2019 Jun 1;142(6):1675-1689. doi: 10.1093/brain/awz084. [PubMed]

Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H. Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy. Front Neural Circuits. 2019 May 8;13:29. doi: 10.3389/fncir.2019.00029. [PubMed]

Kase Y, Otsu K, Shimazaki T, Okano H. Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. Stem Cell Reports. 2019 Apr 23. pii: S2213-6711(19)30132-8. doi: 10.1016/j.stemcr.2019.04.010. [PubMd]

Tamura R, Miyoshi H, Sampetrean O, Shinozaki M, Morimoto Y, Iwasawa C, Fukaya R, Mine Y, Masuda H, Maruyama T, Narita M, Saya H, Yoshida K, Okano H, Toda M. Visualization of spatiotemporal dynamics of human glioma stem cell invasion. Mol Brain. 2019 May 6;12(1):45. doi: 10.1186/s13041-019-0462-3. [PubMed]

Ito R, Nakae K, Hata J, Okano H, Ishii S. Semi-supervised deep learning of brain tissue segmentation. Neural Netw. 2019 Apr 1;116:25-34. doi: 10.1016/j.neunet.2019.03.014. [PubMed]

Hata J, Nakashima D, Tsuji O, Fujiyoshi K, Yasutake K, Sera Y, Komaki Y, Hikishima K, Nagura T, Matsumoto M, Okano H, Nakamura M. Noninvasive technique to evaluate the muscle fiber characteristics using q-space imaging. PLoS One. 2019 Apr 4;14(4):e0214805. doi: 10.1371/journal.pone.0214805. eCollection 2019. [PubMed]

Kojima K, Miyoshi H, Nagoshi N, Kohyama J, Itakura G, Kawabata S, Ozaki M, Iida T, Sugai K, Ito S, Fukuzawa R, Yasutake K, Renault-Mihara F, Shibata S, Matsumoto M, Nakamura M, Okano H. Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury. Stem Cells Transl Med. 2019 Mar;8(3):260-270. doi: 10.1002/sctm.18-0096. [PubMed]

Hata J, Endo K, Tsuji O, Arakawa S, Sato M, Yagi K, Fujiyoshi K, Okano H, Nakamura M. Analysis of skeletal-muscle condition after excessive loading of the lower legs by sequential magnetic resonance imaging. J Orthop Sci. 2019 Mar 13. pii: S0949-2658(19)30067-3. doi: 10.1016/j.jos.2019.01.016. [PubMed]

Abe Y, Komaki Y, Seki F, Shibata S, Okano H, Tanaka KF. Correlative study using structural MRI and super-resolution microscopy to detect structural alterations induced by long-term optogenetic stimulation of striatal medium spiny neurons. Neurochem Int. 2019 Feb 27. pii: S0197-0186(18)30450-9. doi: 10.1016/j.neuint.2019.02.017. [PubMed]

Kitamura K, Nagoshi N, Tsuji O, Matsumoto M, Okano H, Nakamura M. Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment. Int J Mol Sci. 2019 Feb 28;20(5). pii: E1054. doi: 10.3390/ijms20051054. Review. [PubMed]

Miller CT, Hale ME, Okano H, Okabe S, Mitra P. Comparative Principles for Next-Generation Neuroscience. Front Behav Neurosci. 2019 Feb 5;13:12. doi: 10.3389/fnbeh.2019.00012. eCollection 2019. [PubMed]

Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, Miyamoto K, Isomi M, Haginiwa S, Tani H, Kurotsu S, Osakabe R, Torii S, Shimizu S, Okano H, Sugimoto Y, Fukuda K, Ieda M. Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming. Nat Commun. 2019 Feb 20;10(1):674. doi: 10.1038/s41467-019-08626-y. [PubMed]

Komatsu M, Kaneko T, Okano H, Ichinohe N. Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset. J Vis Exp. 2019 Feb 1;(144). doi: 10.3791/58980. [PubMed]

Iwasawa C, Tamura R, Sugiura Y, Suzuki S, Kuzumaki N, Narita M, Suematsu M, Nakamura M, Yoshida K, Toda M, Okano H, Miyoshi H. Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells. Int J Mol Sci. 2019 Feb 14;20(4). pii: E810. doi: 10.3390/ijms20040810. [PubMed]

Sadato N, Morita K, Kasai K, Fukushi T, Nakamura K, Nakazawa E, Okano H, Okabe S. Neuroethical Issues of the Brain/MINDS Project of Japan. Neuron. 2019 Feb 6;101(3):385-389. doi: 10.1016/j.neuron.2019.01.006. [PubMed]

Yoshimatsu S, Okahara J, Sone T, Takeda Y, Nakamura M, Sasaki E, Kishi N, Shiozawa S, Okano H. Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system. Sci Rep. 2019 Feb 6;9(1):1528. doi: 10.1038/s41598-018-37990-w. [PubMed]

Haga Y, Hata J, Uematsu A, Seki F, Komaki Y, Mizumura M, Nishio M, Kaneko T, Kishi N, Okano H, Furukawa A. MR Imaging Properties of ex vivo Common Marmoset Brain after Formaldehyde Fixation. Magn Reson Med Sci. 2019 Feb 7. doi: 10.2463/mrms.mp.2018-0086. [PubMed]

Nishihara K, Shiga T, Nakamura E, Akiyama T, Sasaki T, Suzuki S, Ko MSH, Tada N, Okano H, Akamatsu W. Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem Cell Reports. 2019 Jan 21. pii: S2213-6711(19)30001-3. doi: 10.1016/j.stemcr.2018.12.018. [PubMed]

Iwasawa C, Kuzumaki N, Suda Y, Kagawa R, Oka Y, Hattori N, Okano H, Narita M. Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations. Mol Brain. 2019 Jan 18;12(1):5. doi: 10.1186/s13041-019-0426-7.[PubMed]