Hosoya M, Saeki T, Saegusa C, Matsunaga T, Okano H, Fujioka M, Ogawa K. Estimating the concentration of therapeutic range using disease-specific iPS cells: Low-dose rapamycin therapy for Pendred syndrome. Regen Ther. 2018 Dec 17;10:54-63. doi: 10.1016/j.reth.2018.11.001.[PubMed]
Ito S, Nagoshi N, Tsuji O, Shibata S, Shinozaki M, Kawabata S, Kojima K, Yasutake K, Hirokawa T, Matsumoto M, Takei K, Nakamura M, Okano H. LOTUS Inhibits Neuronal Apoptosis and Promotes Tract Regeneration in Contusive Spinal Cord Injury Model Mice. eNeuro. 2018 Dec 14;5(5). pii: ENEURO.0303-18.2018. doi: 10.1523/ENEURO.0303-18.2018. eCollection 2018 Sep-Oct.[PubMed]
Okubo T, Nagoshi N, Kohyama J, Tsuji O, Shinozaki M, Shibata S, Kase Y, Matsumoto M, Nakamura M, Okano H. Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury. Stem Cell Reports. 2018 Nov 14. pii: S2213-6711(18)30445-4. doi: 10.1016/j.stemcr.2018.10.022. [Epub ahead of print][PubMed]
Tsuji O, Sugai K, Yamaguchi R, Tashiro S, Nagoshi N, Kohyama J, Iida T, Ohkubo T, Itakura G, Isoda M, Shinozaki M, Fujiyoshi K, Kanemura Y, Yamanaka S, Nakamura M, Okano H. Laying the groundwork for a first-in-human study of an iPSC-based intervention for spinal cord injury. Stem Cells. 2018 Oct 29. doi: 10.1002/stem.2926. [Epub ahead of print] Review. [PubMed]
Sakai T, Hata J, Ohta H, Shintaku Y, Kimura N, Ogawa Y, Sogabe K, Mori S, Okano HJ, Hamada Y, Shibata S, Okano H, Oishi K. The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species. Primates. 2018 Oct 24. doi: 10.1007/s10329-018-0694-3. [PubMed]
Hira K, Ueno Y, Tanaka R, Miyamoto N, Yamashiro K, Inaba T, Urabe T, Okano H, Hattori N. Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D2 Synthase. Stroke. 2018 Oct;49(10):2483-2494. doi: 10.1161/STROKEAHA.118.021272. [PubMed]
Tabata Y, Imaizumi Y, Sugawara M, Andoh-Noda T, Banno S, Chai M, Sone T, Yamazaki K, Ito M, Tsukahara K, Saya H, Hattori N, Kohyama J, Okano H. T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease. Stem Cell Reports. 2018 Oct 3. pii: S2213-6711(18)30391-6. doi: 10.1016/j.stemcr.2018.09.006. [PubMed]
Kuwako KI, Okano H. Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis. Front Mol Neurosci. 2018 Oct 2;11:354. doi: 10.3389/fnmol.2018.00354. eCollection 2018. [PubMed]
Majka P, Rosa MGP, Bai S, Chan JM, Huo BX, Jermakow N, Lin MK, Takahashi YS, Wolkowicz IH, Worthy KH, Rajan R, Reser DH, Wójcik DK, Okano H, Mitra PP. Unidirectional monosynaptic connections from auditory areas to the primary visual cortex in the marmoset monkey. Brain Struct Funct. 2018 Oct 4. doi: 10.1007/s00429-018-1764-4. [Epub ahead of print] [PubMed]
Hata J, Mizuno S, Haga Y, Shimoda M, Kanai Y, Chiba K, Okano H, Nakamura M, Horiuchi K. Semiquantitative Evaluation of Muscle Repair by Diffusion Tensor Imaging in Mice. JBMR Plus. 2018 Mar 5;2(4):227-234. doi: 10.1002/jbm4.10040. eCollection 2018 Jul. [PubMed]
Matsubayashi K, Nagoshi N, Komaki Y, Kojima K, Shinozaki M, Tsuji O, Iwanami A, Ishihara R, Takata N, Matsumoto M, Mimura M, Okano H, Nakamura M. Assessing cortical plasticity after spinal cord injury by using resting-state functional magnetic resonance imaging in awake adult mice. Sci Rep. 2018 Sep 26;8(1):14406. doi: 10.1038/s41598-018-32766-8. [PubMed]
Nakamoto FK, Okamoto S, Mitsui J, Sone T, Ishikawa M, Yamamoto Y, Kanegae Y, Nakatake Y, Imaizumi K, Ishiura H, Tsuji S, Okano H. The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy. Sci Rep. 2018 Sep 21;8(1):14215. doi: 10.1038/s41598-018-32573-1. [PubMed]
Tsujimura T, Takase O, Yoshikawa M, Sano E, Hayashi M, Takato T, Toyoda A, Okano H, Hishikawa K. Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c-Bmp7 locus. Epigenetics Chromatin. 2018 Sep 14;11(1):51. doi: 10.1186/s13072-018-0221-1. [PubMed]
Kuwako KI, Okano H. The LKB1-SIK Pathway Controls Dendrite Self-Avoidance in Purkinje Cells. Cell Rep. 2018 Sep 11;24(11):2808-2818.e4. doi: 10.1016/j.celrep.2018.08.029.[PubMed]
Watarai A, Arai N, Miyawaki S, Okano H, Miura K, Mogi K, Kikusui T. Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen’s feces. Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 201720530. doi: 10.1073/pnas.1720530115. [PubMed]
Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, Ushiba J, Okano H. Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys. Cell Rep. 2018 Aug 21;24(8):2191-2195.e4. doi: 10.1016/j.celrep.2018.07.057. [PubMed]
Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H. Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent. Nat Med. 2018 Aug 20. doi: 10.1038/s41591-018-0140-5. [PubMed]
Hosonaga M, Arima Y, Sampetrean O, Komura D, Koya I, Sasaki T, Sato E, Okano H, Kudoh J, Ishikawa S, Saya H, Ishikawa T. HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer. Int J Mol Sci. 2018 Jul 24;19(8). pii: E2158. doi: 10.3390/ijms19082158. [PubMed]
Arioka Y, Shishido E, Kubo H, Kushima I, Yoshimi A, Kimura H, Ishizuka K, Aleksic B, Maeda T, Ishikawa M, Kuzumaki N, Okano H, Mori D, Ozaki N. Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant. Transl Psychiatry. 2018 Jul 19;8(1):129. doi: 10.1038/s41398-018-0177-8. [PubMed]
Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S. Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCN1A gene. Stem Cell Res. 2018 Jun 19;31:11-15. doi: 10.1016/j.scr.2018.06.008.[PubMed]
Kimura H, Ouchi T, Shibata S, Amemiya T, Nagoshi N, Nakagawa T, Matsumoto M, Okano H, Nakamura M, Sato K. Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration. Sci Rep. 2018 Jul 3;8(1):10071. doi: 10.1038/s41598-018-27952-7. [PubMed]
Saito S, Ozawa H, Fujioka M, Hikishima K, Hata J, Kurihara S, Okano HJ, Ogawa K. Visualization of nerve fibers around the carotid bifurcation with use of a 9.4 Tesla microscopic magnetic resonance diffusion tensor imaging with tractography. Head Neck. 2018 Jun 26. doi: 10.1002/hed.25318. [PubMed]
Takata N, Sugiura Y, Yoshida K, Koizumi M, Hiroshi N, Honda K, Yano R, Komaki Y, Matsui K, Suematsu M, Mimura M, Okano H, Tanaka KF. Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation. Glia. 2018 May 30. doi: 10.1002/glia.23454. [PubMed]
O’Day E, Hosta-Rigau L, Oyarzún DA, Okano H, de Lorenzo V, von Kameke C, Alsafar H, Cao C, Chen GQ, Ji W, Roberts RJ, Ronaghi M, Yeung K, Zhang F, Lee SY. Are we there yet? How and when specific biotechnologies will improve human health. Biotechnol J. 2018 May 24:e1800195. doi: 10.1002/biot.201800195. [PubMed]
Tashiro S, Nishimura S, Shinozaki M, Takano M, Konomi T, Tsuji O, Nagoshi N, Toyama Y, Liu M, Okano H, Nakamura M. The Amelioration of Pain-related Behavior in Mice with Chronic Spinal Cord Injury Treated with Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training. J Neurotrauma. 2018 May 23. doi: 10.1089/neu.2017.5537. [PubMed]
Imaizumi K, Fujimori K, Ishii S, Otomo A, Hosoi Y, Miyajima H, Warita H, Aoki M, Hadano S, Akamatsu W, Okano H. Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling. eNeuro. 2018 Apr 26;5(2). pii: ENEURO.0368-17.2018. doi: 10.1523/ENEURO.0368-17.2018. eCollection 2018 Mar-Apr.[PubMed]
de Lorenzo V, Prather KL, Chen GQ, O’Day E, von Kameke C, Oyarzún DA, Hosta-Rigau L, Alsafar H, Cao C, Ji W, Okano H, Roberts RJ, Ronaghi M, Yeung K, Zhang F, Lee SY. The power of synthetic biology for bioproduction, remediation and pollution control: The UN’s Sustainable Development Goals will inevitably require the application of molecular biology and biotechnology on a global scale. EMBO Rep. 2018 Mar 26. pii: e45658. doi: 10.15252/embr.201745658. [Epub ahead of print][PubMed]
Ouchi T, Morikawa S, Shibata S, Takahashi M, Yoshikawa M, Soma T, Miyashita H, Muraoka W, Kameyama K, Kawana H, Arima Y, Saya H, Okano H, Nakagawa T, Asoda S. Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells. J Dent Res. 2018 Feb 1:22034518759278. doi: 10.1177/0022034518759278. [Epub ahead of print][PubMed]
Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M. Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction. Mol Brain. 2018 Feb 20;11(1):6. doi: 10.1186/s13041-018-0349-8. [PubMed]
Tanaka Y, Sone T, Higurashi N, Sakuma T, Suzuki S, Ishikawa M, Yamamoto T, Mitsui J, Tsuji H, Okano H, Hirose S. Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene. Stem Cell Res. 2018 Feb 2;28:100-104. doi: 10.1016/j.scr.2018.01.036. [Epub ahead of print] [PubMed]
Nakatomi M, Quispe-Salcedo A, Sakaguchi M, Ida-Yonemochi H, Okano H, Ohshima H. Nestin expression is differently regulated between odontoblasts and the subodontoblastic layer in mice. Histochem Cell Biol. 2018 Feb 14. doi: 10.1007/s00418-018-1651-3. [Epub ahead of print] [PubMed]
Chai M, Sanosaka T, Okuno H, Zhou Z, Koya I, Banno S, Andoh-Noda T, Tabata Y, Shimamura R, Hayashi T, Ebisawa M, Sasagawa Y, Nikaido I, Okano H, Kohyama J. Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors. Genes Dev. 2018 Jan 15;32(2):165-180. doi: 10.1101/gad.301887.117. Epub 2018 Feb 9. [PubMed]
Ogawa Y, Kakumoto K, Yoshida T, Kuwako KI, Miyazaki T, Yamaguchi J, Konno A, Hata J, Uchiyama Y, Hirai H, Watanabe M, Darnell RB, Okano H, Okano HJ. Elavl3 is essential for the maintenance of Purkinje neuron axons. Sci Rep. 2018 Feb 9;8(1):2722. doi: 10.1038/s41598-018-21130-5. [PubMed]
Hata Y, Ma N, Yoneda M, Morimoto S, Okano H, Murayama S, Kawanishi S, Kuzuhara S, Kokubo Y. Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan. Front Neurosci. 2018 Jan 22;11:751. doi: 10.3389/fnins.2017.00751. eCollection 2017. [PubMed]
Sipp D, Okano H. Japan Strengthens Regenerative Medicine Oversight.Cell Stem Cell. 2018 Feb 1;22(2):153-156. doi: 10.1016/j.stem.2018.01.001.[PubMed]
Takeda H, Hosoya M, Fujioka M, Saegusa C, Saeki T, Miwa T, Okano H, Minoda R. Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice. Sci Rep. 2018 Jan 31;8(1):1941. doi: 10.1038/s41598-018-20277-5.[PubMed]
Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H, Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, Narita M. Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. Mol Pain. 2018 Jan-Dec;14:1744806918756406. doi: 10.1177/1744806918756406. Epub 2018 Jan 22.[PubMed]
Matsuzaki S, Hosoya M, Okano H, Fujioka M, Ogawa K. Expression pattern of EYA4 in the common marmoset (Callithrix jacchus) cochlea. Neurosci Lett. 2018 Jan 1;662:185-188. doi: 10.1016/j.neulet.2017.10.030. Epub 2017 Oct 18. [PubMed]
Cartelli D, Amadeo A, Calogero AM, Casagrande FVM, De Gregorio C, Gioria M, Kuzumaki N, Costa I, Sassone J, Ciammola A, Hattori N, Okano H, Goldwurm S, Roybon L, Pezzoli G, Cappelletti G. Parkin absence accelerates microtubule aging in dopaminergic neurons. Neurobiol Aging. 2018 Jan;61:66-74. doi: 10.1016/j.neurobiolaging.2017.09.010. Epub 2017 Sep 20. [PubMed]
