Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu D, Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M. Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta. Asian Spine J. 2017 Dec;11(6):870-879. doi: 10.4184/asj.2017.11.6.870. Epub 2017 Dec 7. [PubMed]
Yasui T, Mabuchi Y, Morikawa S, Onizawa K, Akazawa C, Nakagawa T, Okano H, Matsuzaki Y. Isolation of dental pulp stem cells with high osteogenic potential. Inflamm Regen. 2017 Apr 10;37:8. doi: 10.1186/s41232-017-0039-4. eCollection 2017. Review. [PubMed]
Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations. Elife. 2017 Nov 28;6. pii: e21114. doi: 10.7554/eLife.21114. [PubMed]
Yamazaki R, Yamazoe K, Yoshida S, Hatou S, Inagaki E, Okano H, Tsubota K, Shimmura S. The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model. Sci Rep. 2017 Nov 14;7(1):15584. doi: 10.1038/s41598-017-15682-1. [PubMed]
Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S. Author Correction: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017 Nov 14;8(1):1598. doi: 10.1038/s41467-017-01594-1. [PubMed]
Kisa F, Shiozawa S, Oda K, Yoshimatsu S, Nakamura M, Koya I, Kawai K, Suzuki S, Okano H. Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation. Stem Cell Reports. 2017 Nov 3. pii: S2213-6711(17)30463-0. doi: 10.1016/j.stemcr.2017.10.008. [PubMed]
Okano H, Kishi N. Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates. Curr Opin Neurobiol. 2017 Nov 7;50:1-6. doi: 10.1016/j.conb.2017.10.016. [Epub ahead of print] Review.[PubMed]
Shimogori T, Abe A, Go Y, Hashikawa T, Kishi N, Kikuchi SS, Kita Y, Niimi K, Nishibe H, Okuno M, Saga K, Sakurai M, Sato M, Serizawa T, Suzuki S, Takahashi E, Tanaka M, Tatsumoto S, Toki M, U M, Wang Y, Windak KJ, Yamagishi H, Yamashita K, Yoda T, Yoshida AC, Yoshida C, Yoshimoto T, Okano H. Digital gene atlas of neonate common marmoset brain. Neurosci Res. 2017 Oct 27. pii: S0168-0102(17)30587-4. doi: 10.1016/j.neures.2017.10.009.[PubMed]
Fujimori K, Matsumoto T, Kisa F, Hattori N, Okano H, Akamatsu W. Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells. Stem Cell Reports. 2017 Oct 24. pii: S2213-6711(17)30431-9. doi: 10.1016/j.stemcr.2017.09.024. [PubMed]
Fukuhara S, Masaoka T, Nishimura S, Nakamura M, Matsuzaki J, Tsugawa H, Miyoshi S, Mori H, Kawase S, Shibata S, Okano H, Kanai T, Suzuki H. Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying. Dig Dis Sci. 2017 Nov 2. doi: 10.1007/s10620-017-4820-7. [PubMed]
Mori T, Sukeda A, Sekine S, Shibata S, Ryo E, Okano H, Suzuki S, Hiraoka N. SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5445-5451. doi: 10.1167/iovs.17-22362. [PubMed]
Cartelli D, Amadeo A, Calogero AM, Casagrande FVM, De Gregorio C, Gioria M, Kuzumaki N, Costa I, Sassone J, Ciammola A, Hattori N, Okano H, Goldwurm S, Roybon L, Pezzoli G, Cappelletti G. Parkin absence accelerates microtubule aging in dopaminergic neurons. Neurobiol Aging. 2017 Sep 20;61:66-74. doi: 10.1016/j.neurobiolaging.2017.09.010. [Epub ahead of print] [PubMed]
Yano R, Hata J, Abe Y, Seki F, Yoshida K, Komaki Y, Okano H, Tanaka KF. Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination.Neurochem Int. 2017 Oct 10. pii: S0197-0186(17)30350-9. doi: 10.1016/j.neuint.2017.10.004.[PubMed]
Itakura G, Ozaki M, Nagoshi N, Kawabata S, Nishiyama Y, Sugai K, Iida T, Kashiwagi R, Ookubo T, Yastake K, Matsubayashi K, Kohyama J, Iwanami A, Matsumoto M, Nakamura M, Okano H. Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells.Sci Rep. 2017 Oct 11;7(1):12996. doi: 10.1038/s41598-017-13522-w.[PubMed]
Hayakawa-Yano Y, Suyama S, Nogami M, Yugami M, Koya I, Furukawa T, Zhou L, Abe M, Sakimura K, Takebayashi H, Nakanishi A, Okano H, Yano M. An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling.Genes Dev. 2017 Sep 15;31(18):1910-1925. doi: 10.1101/gad.300822.117. Epub 2017 Oct 11. [PubMed]
Nagoshi N, Okano H. iPSC-derived neural precursor cells: potential for cell transplantation therapy in spinal cord injury.Cell Mol Life Sci. 2017 Oct 9. doi: 10.1007/s00018-017-2676-9. [Epub ahead of print] Review. [PubMed]
Seki F, Hikishima K, Komaki Y, Hata J, Uematsu A, Okahara N, Yamamoto M, Shinohara H, Sasaki E, Okano H. Developmental trajectories of macroanatomical structures in common marmoset brain.Neuroscience. 2017 Nov 19;364:143-156. doi: 10.1016/j.neuroscience.2017.09.021. Epub 2017 Sep 20.[PubMed]
Renault-Mihara F, Okano H. STAT3-regulated RhoA drives reactive astrocyte dynamics.Cell Cycle. 2017 Sep 21:0. doi: 10.1080/15384101.2017.1377032. [Epub ahead of print] No abstract available.[PubMed]
Uematsu A, Hata J, Komaki Y, Seki F, Yamada C, Okahara N, Kurotaki Y, Sasaki E, Okano H. Mapping orbitofrontal-limbic maturation in non-human primates: A longitudinal magnetic resonance imaging study.Neuroimage. 2017 Dec;163:55-67. doi: 10.1016/j.neuroimage.2017.09.028. Epub 2017 Sep 18. [Epub ahead of print][PubMed]
Iwaoka R, Nagata T, Tsuda K, Imai T, Okano H, Kobayashi N, Katahira M. Backbone and side chain assignments of the second RNA-binding domain of Musashi-1 in its free form and in complex with 5-mer RNA. Biomol NMR Assign. 2017 Oct;11(2):265-268. doi: 10.1007/s12104-017-9760-9. Epub 2017 Aug 14. [PubMed]
Renault-Mihara F, Okano H. STAT3: Down the R(h)oAd. Cytokine. 2017 Aug 10. pii: S1043-4666(17)30229-6. doi: 10.1016/j.cyto.2017.08.003. [Epub ahead of print] No abstract available.[PubMed]
Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H. Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development. Sci Rep. 2017 Jul 28;7(1):6771. doi: 10.1038/s41598-017-06964-9.[PubMed]
Iwaoka R, Nagata T, Tsuda K, Imai T, Okano H, Kobayashi N, Katahira M. Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA. Molecules. 2017 Jul 19;22(7). pii: E1207. doi: 10.3390/molecules22071207.[PubMed]
Shimada H, Kanai R, Kondo T, Yoshino-Saito K, Uchida A, Nakamura M, Ushiba J, Okano H, Ogihara N. Three-dimensional kinematic and kinetic analysis of quadrupedal walking in the common marmoset (Callithrix jacchus). Neurosci Res. 2017 Dec;125:11-20. doi: 10.1016/j.neures.2017.06.005. Epub 2017 Jul 12.[PubMed]
Bamba Y, Kanemura Y, Okano H, Yamasaki M. Visualization of migration of human cortical neurons generated from induced pluripotent stem cells. J Neurosci Methods. 2017 Sep 1;289:57-63. doi: 10.1016/j.jneumeth.2017.07.004. Epub 2017 Jul 8.[PubMed]
Nakajima R, Sato T, Ogawa T, Okano H, Noce T. A noncoding RNA containing a SINE-B1 motif associates with meiotic metaphase chromatin and has an indispensable function during spermatogenesis. PLoS One. 2017 Jun 28;12(6):e0179585. doi: 10.1371/journal.pone.0179585.[PubMed]
Sakai T, Mikami A, Suzuki J, Miyabe-Nishiwaki T, Matsui M, Tomonaga M, Hamada Y, Matsuzawa T, Okano H, Oishi K. Developmental trajectory of the corpus callosum from infancy to the juvenile stage: Comparative MRI between chimpanzees and humans.PLoS One. 2017 Jun 27;12(6):e0179624. doi: 10.1371/journal.pone.0179624.[PubMed]
Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017 Jun 22;8(1):28. doi: 10.1038/s41467-017-00037-1. [PubMed]
Renault-Mihara F, Mukaino M, Shinozaki M, Kumamaru H, Kawase S, Baudoux M, Ishibashi T, Kawabata S, Nishiyama Y, Sugai K, Yasutake K, Okada S, Nakamura M, Okano H. Regulation of RhoA by STAT3 coordinates glial scar formation. J Cell Biol. 2017 Aug 7;216(8):2533-2550. doi: 10.1083/jcb.201610102. Epub 2017 Jun 22. [PubMed]
Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda-Andoh T, Okano H, Nakashima K. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017 Jun 6;8(6):1743-1756. doi: 10.1016/j.stemcr.2017.05.001.[PubMed]
Nori S, Nakamura M, Okano H. Plasticity and regeneration in the injured spinal cord after cell transplantation therapy.Prog Brain Res. 2017;231:33-56. doi: 10.1016/bs.pbr.2016.12.007. Epub 2017 Jan 17.[PubMed]
Shiba-Fukushima K, Ishikawa KI, Inoshita T, Izawa N, Takanashi M, Sato S, Onodera O, Akamatsu W, Okano H, Imai Y, Hattori N. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease. Hum Mol Genet. 2017 Aug 15;26(16):3172-3185. doi: 10.1093/hmg/ddx201.[PubMed]
Ogihara N, Oishi M, Kanai R, Shimada H, Kondo T, Yoshino-Saito K, Ushiba J, Okano H. Muscle architectural properties in the common marmoset (Callithrix jacchus). Primates. 2017 Jul;58(3):461-472. doi: 10.1007/s10329-017-0608-9. Epub 2017 May 8.[PubMed]
Sakai T, Komaki Y, Hata J, Okahara J, Okahara N, Inoue T, Mikami A, Matsui M, Oishi K, Sasaki E, Okano H. Elucidation of developmental patterns of marmoset corpus callosum through a comparative MRI in marmosets, chimpanzees, and humans. Neurosci Res. 2017 Sep;122:25-34. doi: 10.1016/j.neures.2017.04.001. Epub 2017 Apr 9.[PubMed]
Ishikawa KI, Yamaguchi A, Okano H, Akamatsu W. Assessment of Mitophagy in iPS Cell-Derived Neurons. Methods Mol Biol. 2017 Mar 22. doi: 10.1007/7651_2017_10. [Epub ahead of print] [PubMed]
Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophr Res. 2017 Mar;181:75-82. doi: 10.1016/j.schres.2016.10.012. Epub 2016 Oct 27. [PubMed]
Hikishima K, Komaki Y, Seki F, Ohnishi Y, Okano HJ, Okano H. In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain. Sci Rep. 2017 Mar 7;7(1):85. doi: 10.1038/s41598-017-00148-1. [PubMed]
Itakura G, Kawabata S, Ando M, Nishiyama Y, Sugai K, Ozaki M, Iida T, Ookubo T, Kojima K, Kashiwagi R, Yasutake K, Nakauchi H, Miyoshi H, Nagoshi N, Kohyama J, Iwanami A, Matsumoto M, Nakamura M, Okano H. Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives. Stem Cell Reports. 2017 Mar 14;8(3):673-684. doi:10.1016/j.stemcr.2017.02.003. Epub 2017 Mar 2. [PubMed]
Tashiro S, Nakamura M, Okano H. The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models. Neural Regen Res. 2017 Jan;12(1):43-46. doi: 10.4103/1673-5374.198972. Review. [PubMed]
Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G. Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy. J Neurol. 2017 May;264(5):839-847. doi: 10.1007/s00415-017-8405-3. Epub 2017 Feb 22. [PubMed]
Veraitch O, Mabuchi Y, Matsuzaki Y, Sasaki T, Okuno H, Tsukashima A, Amagai M, Okano H, Ohyama M. Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells. Sci Rep. 2017 Feb 21;7:42777. doi: 10.1038/srep42777. [PubMed]
Takano M, Kawabata S, Shibata S, Yasuda A, Nori S, Tsuji O, Nagoshi N, Iwanami A, Ebise H, Horiuchi K, Okano H, Nakamura M. Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction. Stem Cell Reports. 2017 Mar 14;8(3):509-518. doi: 10.1016/j.stemcr.2017.01.013. Epub 2017 Feb 16. [PubMed]
Sato R, Nakano T, Hosonaga M, Sampetrean O, Harigai R, Sasaki T, Koya I, Okano H, Kudoh J, Saya H, Arima Y. RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis. Biomed Res Int. 2017;2017:8032910. doi: 10.1155/2017/8032910. Epub 2017 Jan 22. [PubMed]
Nagoshi N, Okano H. Applications of induced pluripotent stem cell technologies in spinal cord injury. J Neurochem. 2017 Jun;141(6):848-860. doi: 10.1111/jnc.13986. Epub 2017 Apr 5. review[PubMed]
Inagaki E, Hatou S, Higa K, Yoshida S, Shibata S, Okano H, Tsubota K, Shimmura S. Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration. Stem Cells Transl Med. 2017 Mar;6(3):788-798. doi: 10.1002/sctm.16-0162. Epub 2017 Feb 6. [PubMed]
Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, Sobue G. Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell Rep. 2017 Jan 31;18(5):1118-1131. doi: 10.1016/j.celrep.2017.01.013. [PubMed]
Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF. Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation. Nat Commun. 2017 Feb 1;8:14304. doi: 10.1038/ncomms14304. [PubMed]
Iida T, Iwanami A, Sanosaka T, Kohyama J, Miyoshi H, Nagoshi N, Kashiwagi R, Toyama Y, Matsumoto M, Nakamura M, Okano H. Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells. Stem Cells. 2017 Jan 31. doi: 10.1002/stem.2581. [Epub ahead of print] [PubMed]
Kobayashi M, Sumiyama K, Shimojima N, Shimojima N, Ieiri S, Okano H, Kamba S, Fujimura T, Hirobe S, Kuroda T, Takahashi-Fujigasaki J. Technical Feasibility of Visualizing Myenteric Plexus Using Confocal Laser Endomicroscopy. J Gastroenterol Hepatol. 2017 Sep;32(9):1604-1610. doi: 10.1111/jgh.13754.[PubMed]
Ozaki M, Iwanami A, Nagoshi N, Kohyama J, Itakura G, Iwai H, Nishimura S, Nishiyama Y, Kawabata S, Sugai K, Iida T, Matsubayashi K, Isoda M, Kashiwagi R, Toyama Y, Matsumoto M, Okano H, Nakamura M. Evaluation of the immunogenicity of human iPS cell-derived neural stem/progenitor cells in vitro. Stem Cell Res. 2017 Mar;19:128-138. doi: 10.1016/j.scr.2017.01.007. Epub 2017 Jan 19.[PubMed]
Takayama Y, Wakabayashi T, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS. Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors. FEBS Lett. 2017 Feb;591(4):590-602. doi: 10.1002/1873-3468.12572. Epub 2017 Feb 9.[PubMed]
Andoh-Noda T, Akamatsu W, Miyake K, Kobayashi T, Ohyama M, Kurosawa H, Kubota T, Okano H. Differential X Chromosome Inactivation Patterns during the Propagation of Human Induced Pluripotent Stem Cells. Keio J Med. 2017 Mar 25;66(1):1-8. doi: 10.2302/kjm.2016-0015-OA. Epub 2017 Jan 20.[PubMed]
Tanikawa M, Nakahara J, Hata J, Suzuki S, Fujiyoshi K, Fujiwara H, Momoshima S, Jinzaki M, Nakamura M, Okano H, Takahashi S, Suzuki N.q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with fingolimod: A preliminary study. J Neurol Sci. Commun. 2017 Feb 15;373:352-357. doi: 10.1016/j.jns.2017.01.009. [PubMed]
Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa KI, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H.Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons. Biochem Biophys Res Commun. 2017 Jan 29;483(1):88-93. doi: 10.1016/j.bbrc.2016.12.188. [PubMed]
Hosoya M, Fujioka M, Sone T, Okamoto S, Akamatsu W, Ukai H, Ueda HR, Ogawa K, Matsunaga T, Okano H. Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss. Cell Rep. 2017 Jan 3;18(1):68-81. doi: 10.1016/j.celrep.2016.12.020. [PubMed]
