Kspot is an ubiquitin ligase expressed in the nervous system. It induces ubiquitination of substrate molecules within neurons, leading to degradation by proteasomes. In addition, Kspot is considered to be a potential target antigen molecule for the paraneoplastic neurologic syndrome, an autoimmune disease.

kspot.jpg

Contents of Our Work

    RNA-binding protein
  • Functional analysis of Musashi expressed intensely in the neural stem cells
  • Mechanisms for induction of neural differentiation by the Hu protein family
  • Mechanism of mRNA transport and localization to/in neural processes by Hzf
    Ubiquitin ligase
  • Functional analysis of Kspot expressed specifically in the nervous system
    Transcription factors
  • Analysis of Sox21, a transcription factor highly expressed in the neural stem and precursor cells
    Development of methods for the prevention and treatment of hearing loss
  • Research towards regeneration of inner ear hair cells (jointly with the Department of Otorhinolaryngology, School of Medicine, Keio University

Contact

Hirotaka-James Okano（hjokano＠sc.itc.keio.ac.jp）

Pages: 1 2